Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydroxyfumaric acid hydrate 是内源性代谢产物的一种。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 161 | 现货 | ||
500 mg | ¥ 327 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 195 | 现货 |
产品描述 | Dihydroxyfumaric acid is a known generator of superoxide anions and by hydroxyl free radicals. Dihydroxyfumarate exposure can cause insulin inhibitory effects. It can spontaneously convert to hydroxypyruvate or to oxaloglycolate. |
体内活性 | Corynoxine promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Corynoxine promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Corynoxine induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2]. |
分子量 | 166.09 |
分子式 | C4H6O7 |
CAS No. | 199926-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (331.16 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 6.0208 mL | 30.1042 mL | 60.2083 mL | 150.5208 mL |
5 mM | 1.2042 mL | 6.0208 mL | 12.0417 mL | 30.1042 mL | |
10 mM | 0.6021 mL | 3.0104 mL | 6.0208 mL | 15.0521 mL | |
20 mM | 0.301 mL | 1.5052 mL | 3.0104 mL | 7.526 mL | |
50 mM | 0.1204 mL | 0.6021 mL | 1.2042 mL | 3.0104 mL | |
100 mM | 0.0602 mL | 0.301 mL | 0.6021 mL | 1.5052 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dihydroxyfumaric acid hydrate 199926-38-0 Metabolism Others Endogenous Metabolite Dihydroxyfumaric acid Inhibitor inhibit Dihydroxyfumaric acid Hydrate inhibitor